These are markers identifying the point where specific events occurred on the Great Prophetic Timeline.
Jeremiah 31:21 - Set thee up waymarks, make thee high heaps.
1SM 208 - “But the waymarks which have made us what we are, are to be preserved, and they will be preserved, as God has signified through His Word and the testimony of His Spirit. He calls upon us to hold firmly, with the grip of faith, to the fundamental principles that are based upon unquestionable authority.”
RH November 27, 1883 - “Our faith in reference to the messages of the first, second, and third angels was correct. The great waymarks we have passed are immovable. Although the hosts of hell may try to tear them from their foundation, and triumph in the thought that they have succeeded, yet they do not succeed.”
2SM 101, 102 - “The great waymarks of truth, showing us our bearings in prophetic history, are to be carefully guarded, lest they be torn down, and replaced with theories that would bring confusion rather than genuine light.”
Mar 161 - “We should study the great waymarks that point out the times in which we are living. . . . We should now pray most earnestly that we may be prepared for the struggles of the great day of God's preparation.”